Stripping GSH?
26/07/10 10:24
I figure I might as well answer some questions that have been posed, before, and answered (incorrectly) on other forums. These incorrect answers, particularly, came from the forums relating to the use of glutathione for treatment of CF.
Years ago, when I first began studying this disease, I came upon the information, published by Hanrahan and Linsdell, that the CFTR transported glutathione. Well, actually, the article stated that the CFTR protein was “permeable” to glutathione, and I extrapolated from that that the CFTR transported the tripeptide. Many, many experiments have since shown this to be absolutely correct. The CFTR transports glutathione.
At this time, some went on their merry way of championing the use of glutathione in the treatment of cystic fibrosis. And Sharktank went on its way of actually studying this disease in its entirety, because we knew that glutathione was only part of the answer. I recently read a few things about CF and BITC on the internet. I came across some sites where people were questioning if BITC “stripped” glutathione from the cells.
I hope that I have taught you enough about the science of these proteins, and CF, to realize how funny that idea is. Don’t get me wrong—I know it’s a scare tactic—but I want you to be able to see it, logically, alongside all of the other things that we know about the CFTR protein, and if you can do that, you will see how funny it is.
Let’s begin to line up the facts here, and you will see the joke:
1. The CFTR transports glutathione
2. The MRP transports glutathione
3. The “stripping” of glutathione from the cells is caused by the transport of glutathione from these cells, by both of these proteins.
So, it logically follows that if the CFTR transports glutathione, and MRP transports glutathione, and this transport is characterized, in other terms, as “stripping,” then BOTH proteins do this. If you can say that the MRP’s transport of glutathione is “stripping,” then you must also characterize the CFTR’s transport of glutathione as “stripping.”
If one is good, then how can the other be bad, if they are the same?
The key here is the word “strip.” It is a word laden with emotion. I won’t even begin to guess why someone would use such a word in this context, but I would suggest to you that you consider their motives. And then you determine whether you want to believe anything else that this person says about BITC.
I am not in love with my theory. That is not the way to finding the truth, and to crushing this disease. It is the way of the zealot. And no one wins if we stop seeking the truth, and, instead, begin to try to convince people by politicking.
I know, however, that there are people out there who know just little enough to be afraid when they hear words like “strip.” This post is for you. There are the facts; they are well known and well documented, in the scientific literature.
Put them together and come to your own conclusion.
Years ago, when I first began studying this disease, I came upon the information, published by Hanrahan and Linsdell, that the CFTR transported glutathione. Well, actually, the article stated that the CFTR protein was “permeable” to glutathione, and I extrapolated from that that the CFTR transported the tripeptide. Many, many experiments have since shown this to be absolutely correct. The CFTR transports glutathione.
At this time, some went on their merry way of championing the use of glutathione in the treatment of cystic fibrosis. And Sharktank went on its way of actually studying this disease in its entirety, because we knew that glutathione was only part of the answer. I recently read a few things about CF and BITC on the internet. I came across some sites where people were questioning if BITC “stripped” glutathione from the cells.
I hope that I have taught you enough about the science of these proteins, and CF, to realize how funny that idea is. Don’t get me wrong—I know it’s a scare tactic—but I want you to be able to see it, logically, alongside all of the other things that we know about the CFTR protein, and if you can do that, you will see how funny it is.
Let’s begin to line up the facts here, and you will see the joke:
1. The CFTR transports glutathione
2. The MRP transports glutathione
3. The “stripping” of glutathione from the cells is caused by the transport of glutathione from these cells, by both of these proteins.
So, it logically follows that if the CFTR transports glutathione, and MRP transports glutathione, and this transport is characterized, in other terms, as “stripping,” then BOTH proteins do this. If you can say that the MRP’s transport of glutathione is “stripping,” then you must also characterize the CFTR’s transport of glutathione as “stripping.”
If one is good, then how can the other be bad, if they are the same?
The key here is the word “strip.” It is a word laden with emotion. I won’t even begin to guess why someone would use such a word in this context, but I would suggest to you that you consider their motives. And then you determine whether you want to believe anything else that this person says about BITC.
I am not in love with my theory. That is not the way to finding the truth, and to crushing this disease. It is the way of the zealot. And no one wins if we stop seeking the truth, and, instead, begin to try to convince people by politicking.
I know, however, that there are people out there who know just little enough to be afraid when they hear words like “strip.” This post is for you. There are the facts; they are well known and well documented, in the scientific literature.
Put them together and come to your own conclusion.